|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 236 of Human S6K|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28597 targets S6K in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-28597 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 236 of Human S6K.
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 70 kDa ribosomal protein S6 kinase 1; alpha 1; alpha 2; p70 ribosomal S6 kinase alpha; p70 S6 kinase; p70 S6 kinase alpha; p70 S6 kinase, alpha; p70 S6K-alpha; p70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; p70-S6K 1; P70S6K; P70S6K1; PS6K; Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase I; ribosomal protein S6 kinase, 70kD, polypeptide 1; ribosomal protein S6 kinase, 70kDa, polypeptide 1; S6 kinase; S6K; S6K-beta-1; S6K1; serine/threonine kinase 14 alpha; serine/threonine-protein kinase; Serine/threonine-protein kinase 14A; STK14A
Gene Aliases: 2610318I15Rik; 4732464A07Rik; 70kDa; AA959758; AI256796; AI314060; p70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; p70/85s6k; p70s6k; PS6K; RPS6KB1; S6K; S6K-beta-1; S6K1; STK14A
Molecular Function: annexin calcium-binding protein calmodulin intracellular calcium-sensing protein kinase non-receptor serine/threonine protein kinase protein kinase transfer/carrier protein transferase
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