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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 108-139 amino acids from the N-terminal region of human SAD1 (BRSK1)|
|Purification||Ammonium sulfate precipitation, Size-exclusion - Dialysis|
|Contains||0.09% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is predicted to react with mouse and rat based on sequence homology.
BRSK1 may be involved as a checkpoint kinase in the regulation of G2/M arrest in response to UV- or methyl methane sulfonate (MMS)-induced, but not IR-induced, DNA damage. This protein phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo. BRSK1 is partitioned between cytoplasmic and nuclear locations in the absence of DNA damage, but translocates to the nucleus in response to Uv- or MMS-induced DNA damage. BRSK1 shares significant homology with the fission yeast Cdr2, a mitosis-regulatory kinase, and Caenorhabditis elegans SAD1, a neuronal cell polarity regulator. The BRSK1 transcript is expressed ubiquitously with the highest levels of expression in brain and testis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
BR serine/threonine-protein kinase 1; brain-selective kinase 1; brain-specific serine/threonine-protein kinase 1; BRSK1; protein kinase SAD1A; SAD1 homolog; SAD1 kinase; SAD1A; SadB kinase short isoform; serine/threonine kinase SAD-B; serine/threonine kinase SADB; serine/threonine-protein kinase BRSK1; serine/threonine-protein kinase SAD-B; synapses of Amphids Defective homolog 1
BRSK1; Gm1100; hSAD1; KIAA1811; SAD-B; SAD1; SADB