Small ubiquitin-like modifiers (SUMOs) are a family of small, related proteins (SUMO-1/2/3/4) that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation, a major regulator of protein function in cellular processes such as nuclear transport, transcriptional regulation, apoptosis and protein stability. This sumoylation is effected by the heterodimeric enzyme SAE1/SAE2 and the SUMO-1-conjugating enzyme Ubch9. The sumoylation pathway mediated by SAE1/SAE2 is distinct from other ubiquitin-like protein (Ubl) pathways.
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Protein Aliases: activator of SUMO1; AOS1; FLJ3091; HSPC140; SAE1; sentrin/SUMO-activating protein AOS1; SUA1; SUMO-1 activating enzyme E1 N subunit; SUMO-1 activating enzyme subunit 1; SUMO-activating enzyme subunit 1; SUMO-activating enzyme subunit 1, N-terminally processed; SUMO1 activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A; ubiquitin-like protein SUMO-1 activating enzyme; UBLE1A
Gene Aliases: AOS1; HSPC140; SAE1; SUA1; UBLE1A
UniProt ID: (Human) Q9UBE0
Entrez Gene ID: (Human) 10055