Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CHBL2; DCIP; Dendritic cell-derived IFNG-induced protein; Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; dNTPase; HDDC1; hSAMHD1; Monocyte protein 5; MOP-5; RP1-132F21.1; SAM domain and HD domain 1; SAM domain and HD domain-containing protein 1; SBBI88
Gene Aliases: CHBL2; DCIP; HDDC1; MOP-5; MOP5; SAMHD1; SBBI88
UniProt ID: (Human) Q9Y3Z3
Entrez Gene ID: (Human) 25939