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SCP2 Antibody (MA5-44821) in IHC (P)
Immunohistochemistry analysis of Sterol carrier protein 2 in paraffin-embedded human small intestine tissue. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody Sterol carrier protein 2 Monoclonal antibody (Pr... View More
Product Details
MA5-44821
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JE62-79
Immunogen
Synthetic peptide within human Sterol carrier protein 2 aa 14-64/547.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2931278
Target Information
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acetyl-CoA C-myristoyltransferase; Non-specific lipid-transfer protein; nonspecific lipid transfer protein; NSL-TP; Propanoyl-CoA C-acyltransferase; SCP-2; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-chi; SCP-X; SCPX; Sterol carrier protein 2; Sterol carrier protein X
Gene Aliases: AA409774; AA409893; C76618; C79031; NLTP; ns-LTP; NSL-TP; SCP-2; SCP-CHI; SCP-X; SCP2; SCPX
UniProt ID: (Human) P22307, (Mouse) P32020
Entrez Gene ID: (Human) 6342, (Mouse) 20280
fatty-acyl-CoA binding
receptor binding
protein binding
sterol transporter activity
cholesterol binding
propanoyl-CoA C-acyltransferase activity
long-chain fatty acyl-CoA binding
propionyl-CoA C2-trimethyltridecanoyltransferase activity
oleic acid binding
catalytic activity
acetyl-CoA C-acyltransferase activity
lipid binding
phosphatidylcholine transporter activity
phosphatidylinositol transporter activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
cholesterol transporter activity
protein homodimerization activity
protein heterodimerization activity
phosphatidylethanolamine transporter activity
acyltransferase
transfer/carrier protein
bile acid biosynthetic process
peroxisome organization
sterol transport
positive regulation of intracellular cholesterol transport
fatty acid beta-oxidation using acyl-CoA oxidase
alpha-linolenic acid metabolic process
lipid hydroperoxide transport
acyl-CoA metabolic process
steroid biosynthetic process
progesterone biosynthetic process
transport
lipid transport
aging
metabolic process
positive regulation of steroid biosynthetic process
phospholipid transport
cholesterol transport
inositol trisphosphate biosynthetic process
positive regulation of apoptotic process
positive regulation of cholesterol biosynthetic process
positive regulation of steroid metabolic process
protein localization to plasma membrane
positive regulation of cholesterol import
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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