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|Tested species reactivity||Bovine, C. elegans, Human, Mouse, Rat|
|Published species reactivity||Rat, Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Bovine Heart Complex II, with traces of Complex III|
|Storage buffer||HEPES buffered saline|
|Contains||0.02% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay Dependent|
|Western Blot (WB)||1.0 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
SDHA is an important component in the citric acid cycle and respiratory chain. SDHA converts succinate to fumarate, transfers electrons in the respiratory chain, and ultimately transfers electrons to ubiquinone. SDHA is localized within the mitochondrial inner membrane. Mutations in the gene have been associated with Leigh syndrome and Huntington's disease. However, SDHA also appears to have tumor suppressor effects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice.
459200 was used in western blot to study how OMA1 links mitochondrial morphology and cardiac metabolism.
|Wai T,García-Prieto J,Baker MJ,Merkwirth C,Benit P,Rustin P,Rupérez FJ,Barbas C,Ibañez B,Langer T||Science (New York, N.Y.) (350:null)||2015|
Dynamics of enhanced mitochondrial respiration in female compared with male rat cerebral arteries.
459200 was used in western blot to test if mitochondrial energetics of large cerebral arteries are sex dependent.
|Rutkai I,Dutta S,Katakam PV,Busija DW||American journal of physiology. Heart and circulatory physiology (309:H1490)||2015|
AMP-activated protein kinase controls exercise training- and AICAR-induced increases in SIRT3 and MnSOD.
459200 was used in western blot to test the requirement of AMP-activated protein kinase for exercise training-induced increases in skeletal muscle abundance of mitochondrial proteins.
|Brandauer J,Andersen MA,Kellezi H,Risis S,Frøsig C,Vienberg SG,Treebak JT||Frontiers in physiology (6:null)||2015|
Overexpression of TFAM or twinkle increases mtDNA copy number and facilitates cardioprotection associated with limited mitochondrial oxidative stress.
459200 was used in western blot to assess the role of mtDNA copy number in heart failure
|Ikeda M,Ide T,Fujino T,Arai S,Saku K,Kakino T,Tyynismaa H,Yamasaki T,Yamada K,Kang D,Suomalainen A,Sunagawa K||PloS one (10:null)||2015|
Identification of mitochondrial dysfunction in Hutchinson-Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture.
459200 was used in western blot to elucidate the mechanisms underlying cellular damage and senescence and accelerated aging in Hutchinson-Gilford progeria syndrome.
|Rivera-Torres J,Acín-Perez R,Cabezas-Sánchez P,Osorio FG,Gonzalez-Gómez C,Megias D,Cámara C,López-Otín C,Enríquez JA,Luque-García JL,Andrés V||Journal of proteomics (91:466)||2013|
Irgm1 (LRG-47), a regulator of cell-autonomous immunity, does not localize to mycobacterial or listerial phagosomes in IFN-γ-induced mouse cells.
459200 was used in immunocytochemistry to determine if Irgm targets mycobacterial and listerial phagosomes.
|Springer HM,Schramm M,Taylor GA,Howard JC||Journal of immunology (Baltimore, Md. : 1950) (191:1765)||2013|
Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses.
459200 was used in immunohistochemistry - paraffin section to investigate the effects of mitochondrial DNA damage on hippocampal neurons.
|Lauritzen KH,Cheng C,Wiksen H,Bergersen LH,Klungland A||DNA repair (10:639)||2011|
CMD1GG; Flavoprotein subunit of complex II; Fp; mitochondrial; PGL5; SDH1; SDH2; SDHF; succinate dehydrogenase [ubiquinone] flavoprotein subunit; Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; succinate dehydrogenase complex flavoprotein subunit; succinate dehydrogenase complex subunit A; succinate dehydrogenase complex subunit A, flavoprotein (Fp); succinate dehydrogenase complex, subunit A, flavoprotein (Fp); succinate dehydrogenase flavoprotein subunit A
1500032O14Rik; 2310034D06Rik; 4921513A11; BOS_19942; C81073; CMD1GG; FP; PGL5; SDH1; SDH2; SDHA; SDHF; SDHFP1