This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
Positive control: Human heart mitochondria.
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
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Protein Aliases: FLJ92337; IP; iron-sulfur subunit; Iron-sulfur subunit of complex II; OTTHUMP00000044624; SDHB; sdhB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; succinate dehydrogenase complex subunit B; succinate dehydrogenase complex subunit B, iron sulfur (Ip); succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Gene Aliases: 0710008N11Rik; CWS2; fj46d06; I79_022285; IP; PGL4; SDH; SDH1; SDH2; SDHB; SDHIP; wu:fj46d06
Molecular Function: dehydrogenase