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SDS encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver.
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Protein Aliases: L-serine ammonia-lyase; L-serine deaminase; L-serine dehydratase; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; SDH; TDH
Gene Aliases: SDH; SDS
UniProt ID: (Human) P20132
Entrez Gene ID: (Human) 10993
Molecular Function: dehydratase