SUMO is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1, SUMO2, and SUMO3 into the conjugatable mature forms and catalyze the deconjugation of these same SUMO proteins from their targeted substrates. SENP2 may also down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.
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Protein Aliases: Axam2; CT; Sentrin-specific protease 2; Sentrin/SUMO-specific protease SENP2; SMT3-specific isopeptidase 2; Smt3ip2; SUMO1/sentrin/SMT3 specific protease 2
Gene Aliases: AXAM2; KIAA1331; SENP2; SMT3IP2
UniProt ID: (Human) Q9HC62
Entrez Gene ID: (Human) 59343
Molecular Function: protease