PA5-29380 targets SERCA2 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-29380 immunogen is recombinant fragment corresponding to a region within amino acids 237 and 538 of Human SERCA2.
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This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Protein Aliases: ATP2B; ATPase Ca++ transporting cardiac muscle slow twitch 2; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; Ca++ dependent; Calcium pump 2; calcium-transporting ATPase sarcoplasmic reticulum type; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; cardiac Ca2+ ATPase; cardiac muscle-2; DAR; DD; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarcopla; Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; slow twitch skeletal muscle isoform; slow-twitch; SR Ca(2+)-ATPase 2
Gene Aliases: ATP2A2; ATP2B; DAR; DD; SERCA2
UniProt ID: (Human) P16615
Entrez Gene ID: (Human) 488