|Tested species reactivity||Human, Mouse, Rabbit, Rat|
|Host / Isotype||Mouse / IgG1|
|Storage buffer||PBS with 0.1% BSA|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Functional Assay (FN)||1:50|
|Immunohistochemistry (Frozen) (IHC (F))||1:50|
|Western Blot (WB)||1:50|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-40224 detects PAI-1 from human, rat, mouse and rabbit samples.
MA1-40224 has been successfully used in ELISA, functional studies, immunohistochemistry (frozen) and Western blot applications.
The MA1-40224 immunogen is human PAI-1.
PAI (plasminogen activator inhibitor) belongs to serine protease inhibitor superfamily, and is the principal inhibitor of tissue-type and urokinase-type plasminogen activators (tPA and uPA). Platelets are the main source of the circulating PAI-1, but it is synthesized and secreted by many tissue and cell types, including fibroblasts, smooth muscle cells, endothelial cells, hepatocytes, and inflammatory cells. Expression of PAI-1 can be regulated at the transcriptional level by many factors including growth factors, cytokines, hormones, inflammatory factors, glucose or lipid metabolites, vascular tone regulating factors, chemicals, and other environmental or physical factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.