This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GDN; GDN_HUMAN; Glia derived nexin; Glia-derived nexin; glial-derived neurite promoting factor; P17; Peptidase inhibitor 7; PI-7; Plasminogen activator inhibitor type 1, member 2; PN-1; PNI; Protease inhibitor 7; Protease nexin 1; Protease nexin I; protease nexin-1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; serine (or cysteine) proteinase inhibitor, clade E, member 2; serine protease inhibitor 4; Serine protease-inhibitor 4; Serpin E2; Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; SERPINE 2; Serpine2
Gene Aliases: B230326M24Rik; GDN; GDNPF; PAI-1; PI-7; PI7; PN-1; PN1; PNI; SERPINE2; Spi4