The frizzled gene, originally identified in Drosophila melanogaster, was shown to be involved in the development of tissue polarity. The mammalian homolog of frizzled, as well as several secreted, mammalian, frizzled-related proteins such as FRP-1 (also designated SARP2), FRP-2 (also designated SARP1), FRP-3, FRP-4 and SARP3 (also designated FRP-5), have been identified. The frizzled proteins contain seven transmembrane domains and a cysteine-rich domain in the extra carboxy-terminal Ser/Thr-xxx-Val motif, and they function as receptors for Wnt. The frizzled-1 gene maps to human chromosome 7q21 and is expressed in adult heart, placenta, lung, kidney, pancreas, prostate and ovary, as well as in fetal lung and kidney. Frizzled-2 is expressed in adult heart and fetal brain, lung and kidney. The frizzled-related proteins FRP-1, FRP-2, FRP-3, FRP-4 and SARP3 are secreted proteins that contain regions of homology to the cysteine-rich, ligand-binding domain of frizzled and a conserved, hydrophilic carboxy-terminus. The gene encoding human SARP3 maps to chromosome 4q31.3 and is expressed in retinal pigment epithelium (RPE) and pancreas, while expression of FRP-1, 2 and 4 is high in developing tissues. The FRPs/SARPs are involved in the Wnt signaling pathway by regulating the intracellular levels of beta-catenin.
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Protein Aliases: Frizzled related protein 2; FRP 2; FRP-2; FRP2; MGC128911; MGC153618; MGC53344; SARP 1; SARP-1; SARP1; SDF 5; SDF5; Secreted apoptosis related protein 1; Secreted apoptosis-related protein 1; Secreted frizzled related protein 2; Secreted frizzled-related protein 2; sFRP 2; sFRP-2; SFRP2; Sfrp2 protein; testicular tissue protein Li 170
Gene Aliases: FKSG12; FRP-2; FRP2; SARP1; SDF-5; SFRP2; UNQ361/PRO697
UniProt ID: (Human) Q96HF1
Entrez Gene ID: (Human) 6423