Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
- | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunocytochemistry (ICC/IF) |
1:10-1:100 | - |
Flow Cytometry (Flow) |
0.2 µg/1x10^6 cells | - |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
SGK1 Fusion Protein Ag17888 (1-431 aa encoded by BC001263) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.41 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
This antibody is specific to SGK1.
Immunogen sequence: MTVKTEAAK GTLTYSRMRG MVAILIAFMK QRRMGLNDFI QKIANNSYAC KHPEVQSILK ISQPQEPELM NANPSPPPSP SQQINLGPSS NPHAKPSDFH FLKVIGKGSF GKVLLARHKA EEVFYAVKVL QKKAILKKKE EKHIMSERNV LLKNVKHPFL VGLHFSFQTA DKLYFVLDYI NGGELFYHLQ RERCFLEPRA RFYAAEIASA LGYLHSLNIV YRDLKPENIL LDSQGHIVLT DFGLCKENIE HNSTTSTFCG TPEYLAPEVL HKQPYDRTVD WWCLGAVLYE MLYGLPPFYS RNTAEMYDNI LNKPLQLKPN ITNSARHLLE GLLQKDRTKR LGAKDDFMEI KSHVFFSLIN WDDLINKKIT PPFNPNVSGP NDLRHFDPEF TEEPVPNSIG KSPDSVLVTA SVKEAAEAFL GFSYAPPTDS FL (1-431 aa encoded by BC001263)
Serum and glucocorticoid-regulated protein kinase 1 (SGK1) is a member of the AGC family of serine/threonine kinases that plays an important role in cellular stress response and cell survival. SGK1 is transcriptionally activated by numerous stimuli, including serum, glucocorticoids, osmotic stress, and hormones. SGK1 functions as a regulator of cell survival and ion channels and transporters such as ENaC or KCNA3/Kv1. 3. It phosphorylates and negatively regulates pro-apoptotic FOXO3A. SGK1 is thought to play an essential function in nephropathy and cardiovascular development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: serine/threonine protein kinase SGK; Serine/threonine-protein kinase Sgk1; serum and glucocorticoid-dependent protein kinase; Serum/glucocorticoid-regulated kinase 1; Sgk1 variant i3
Gene Aliases: SGK; SGK1
UniProt ID: (Human) O00141, (Mouse) Q9WVC6
Entrez Gene ID: (Human) 6446, (Mouse) 20393
Molecular Function:
protein modifying enzyme
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