Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Adapter protein TKS5; adaptor protein TKS5; FISH; Five SH3 domain-containing protein; SH3 and PX domain-containing protein 2A; SH3 multiple domains 1; SH3 multiple domains protein 1; SH3MD1; TKS5; Tyrosine kinase substrate with five SH3 domains
Gene Aliases: FISH; KIAA0418; SH3MD1; SH3PXD2A; TKS5
UniProt ID: (Human) Q5TCZ1
Entrez Gene ID: (Human) 9644