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1 µg/mL of MA5-45446 was sufficient for detection of Shank1 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 190-220 kDa (alternative splice variants). No cross-reactivity against Shank2 or Shank3.
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; OTTHUMP00000174437; SAPAP-interacting protein synamon; SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains protein 1; SH3/ankyrin domain gene 1; SHANK 1; Shank1; Somatostatin receptor-interacting protein; SPANK 1; SPANK-1; SSTR-interacting protein; Synamon
Gene Aliases: SHANK1; Shank1a; SPANK-1; Spank1; SSTRIP; synamon
UniProt ID: (Human) Q9Y566, (Rat) Q9WV48, (Mouse) D3YZU1
Entrez Gene ID: (Human) 50944, (Rat) 78957, (Mouse) 243961
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