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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Residues between 350 and the C-terminus (412) of human DEC1 using the numbering given in entry NP_003661.1 (GeneID 8553)|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7-8|
|Contains||0.09% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay-Dependent|
|Western Blot (WB)||1:5000-1:15,000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Suggested positive control: antigen standard for BHLHB2 (transient overexpression lysate).
Differentiated embryo-chondrocyte expressed gene 1 (DEC1) is an important protein involved in embryonic cell differentiation, proliferation, and apoptosis. It has also recently been shown to be regulated by hypoxia. The loss of DEC1 expression may be an early event in the development of lung cancer, while DEC1 may be up-regulated by hypoxia in other cancers and in more extreme hypoxia it may have a role in cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Basic Helix-Loop-Helix Domain Containing; basic helix-loop-helix domain containing, class B, 2; basic helix-loop-helix family, member e40; BHLHB2; bHLHe40; Class B basic helix-loop-helix protein 2; Class E basic helix-loop-helix protein 40; DEC-1; DEC1; Differentially Expressed in Chondrocytes; differentially expressed in chondrocytes 1; Differentially expressed in chondrocytes protein 1; differentiated embryo chondrocyte expressed gene 1; Differentiated Embryo Chrondrocyte Expressed Gene 1; Enhancer-of-split and hairy-related protein 2; SHARP-2; Stimulated by retinoic acid gene 13 protein
BHLHB2; BHLHE40; DEC1; HLHB2; SHARP-2; SHARP2; STRA13; Stra14