Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds – the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody – recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets – a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
Sonic Hedgehog (SHH) is a secreted signaling protein belonging to Hedgehog family. It plays an important role in patterning and organogenesis during embryonic development. In adult cells, SHH plays a role in control of cell division. The hedgehog signalling pathway is initiated when SHH binds the Patched receptor (PTC) resulting in release of SMO from repression. SMO acts to inhibit proteolytic cleavage of the Ci protein which acts as a transcriptional activator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HHG-1; HHG1; HPE3; MCOPCB5; SHH; Shh N-terminal processed signaling domains; Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; ShhN; ShhNC; ShhNp; SMMCI; sonic hedgehog homolog; Sonic hedgehog protein; Sonic hedgehog protein N-product; TPT; TPTPS
Gene Aliases: HHG1; HLP3; HPE3; MCOPCB5; SHH; SMMCI; TPT; TPTPS; Vhh-1