MA5-17160 targets PTPN11 in FACS, ICC, IHC, IF and WB applications and shows reactivity with Human samples.
The MA5-17160 immunogen is purified recombinant fragment of human PTPN11 (amino acids: 263-329) expressed in E. Coli.
MA5-17160 detects PTPN11 which has a predicted molecular weight of approximately 68.4kDa.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; PTP-1D; PTP-2C; SH-PTP2; SH-PTP3; SHP-2; Tyrosine-protein phosphatase non-receptor type 11
Gene Aliases: BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; PTPN11; SH-PTP2; SH-PTP3; SHP2; SHPTP2
UniProt ID: (Human) Q06124
Entrez Gene ID: (Human) 5781