|Tested species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide: D(515) K T K K Q A V G S P R K I E K E L R K S(535)|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:250|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-4315 detects the SHPRH protein in mouse samples.
PA1-4315 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~200 kDa protein representing SHPRH in mouse brain lysate.
PA1-4315 immunizing peptide corresponds to amino acid residues 515-535 of the mouse SHPRH protein. There is 95% sequence identity to rat, and 90% sequence identity to human.
A novel gene containing SNF2, PHD-finger, RING-finger, helicase, and linker histone domains termed SHPRH, is a possible candidate for a tumor suppressor gene. These domains are characteristic of several DNA repair proteins, transcription factors, and helicases. Mapping of this gene to 6q24, a region reported to contain a tumor suppressor locus suggests a role in tumor suppression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.