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|Tested species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (YDQERFDNSDLSA) corresponding to the C-terminus amino acids of PUF60|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.1-0.3 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology.
The protein encoded by this gene is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
FBP interacting repressor; FIR; FLJ31379; FUSE-binding protein-interacting repressor; poly(U) binding splicing factor 60KDa; poly-U binding splicing factor 60KDa; poly-U binding splicing factor PUF60; PUF60; pyrimidine tract binding splicing factor; Ro ribonucleoprotein binding protein 1; Ro ribonucleoprotein-binding protein 1; RoBPI; Siah binding protein 1; SIAHBP1
FIR; PUF60; ROBPI; SIAHBP1; VRJS