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| Applications | Tested Dilution | Publications |
|---|---|---|
ELISA (ELISA) |
Assay-Dependent | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG2a, kappa |
Class |
Monoclonal |
Type |
Antibody |
Clone |
2C11 |
Immunogen |
SIN3B (NP_056075.1, 1063 a.a. ~ 1160 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.2-1.0 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.4 |
Contains |
no preservative |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2610080 |
Peptide Sequence: HKMVFIVNSE DYMYRRGTLC RAKQVQPLVL LRHHQHFEEW HSRWLEDNVT VEAASLVQDW LMGEEDEDMV PCKTLCETVH VHGLPVTRYR VQYSRRPA
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Histone deacetylase complex subunit Sin3b; Paired amphipathic helix protein Sin3b; SIN3 homolog B, transcriptional regulator; SIN3 transcription regulator homolog B; SIN3B; Transcriptional corepressor Sin3b
Gene Aliases: KIAA0700; SIN3B
UniProt ID: (Human) O75182
Entrez Gene ID: (Human) 23309
Molecular Function:
chromatin/chromatin-binding, or -regulatory protein
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