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Product Specifications | |
---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG2b |
Class |
Monoclonal |
Type |
Antibody |
Clone |
7F6G6 |
Immunogen |
SIRT1 Fusion Protein Ag17677 (1-350 aa encoded by BC012499) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1.2 mg/mL |
Purification |
Protein A |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human SIRT1.
Immunogen sequence: MIGTDPRTI LKDLLPETIP PPELDDMTLW QIVINILSEP PKRKKRKDIN TIEDAVKLLQ ECKKIIVLTG AGVSVSCGIP DFRSRDGIYA RLAVDFPDLP DPQAMFDIEY FRKDPRPFFK FAKEIYPGQF QPSLCHKFIA LSDKEGKLLR NYTQNIDTLE QVAGIQRIIQ CHGSFATASC LICKYKVDCE AVRGALFSQV VPRCPRCPAD EPLAIMKPEI VFFGENLPEQ FHRAMKYDKD EVDLLIVIGS SLKVRPVALI PSSIPHEVPQ ILINREPLPH LHFDVELLGD CDVIINELCH RLGGEYAKLC CNPVKLSEIT EKPPRTQKEL AYLSELPPTP LHVSEDSSSP E (1-350 aa encoded by BC012499)
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, repsonse to DNA damage, metabolism, apoptosis, and autophagy. SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 75SirT1; hSIR2; hSIRT1; NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; RP11-57G10.3; SIR2-like protein 1; SIRT 1; SIRT-1; SirtT1 75 kDa fragment; sirtuin type 1
Gene Aliases: SIR2; SIR2alpha; SIR2L1; SIRT1
UniProt ID: (Human) Q96EB6
Entrez Gene ID: (Human) 23411
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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