Immunogen sequence: MDFLRNLFS QTLSLGSQKE RLLDELTLEG VARYMQSERC RRVICLVGAG ISTSAGIPDF RSPSTGLYDN LEKYHLPYPE AIFEISYFKK HPEPFFALAK ELYPGQFKPT ICHYFMRLLK DKGLLLRCYT QNIDTLERIA GLEQEDLVEA HGTFYTSHCV SASCRHEYPL SWMKEKIFSE VTPKCEDCQS LVKPDIVFFG ESLPARFFSC MQSDFLKVDL LLVMGTSLQV QPFASLISKA PLSTPRLLIN KEKAGQSDPF LGMIMGLGGG MDFDSKKAYR DVAWLGECDQ GCLALAELLG WKKELEDLVR REHASIDAQS GAGVPNPSTS ASPKKSPPPA KDEARTTERE KPQ (1-352 aa encoded by BC003547)
The SIRT2 protein (also known as Sirtuin for Silent Mating Type Information 2-Homolog) is a NAD-dependent deacytylase (NDAC) that has been shown to control gene silencing, cell cycle, and DNA damage repair. It is believed that SIRT2 may act as a tumor suppressor in human gliomas and may also serve as a novel molecular marker for these cells. SIRT2 has also been shown to act as a redox sensor to help regulate muscle gene expression in response to food intake and exercise. SIRT2 acts in the phosphorylation cascade involving mitosis where SIRT2 is phosphorylated in late G2 phase, during M phase, and into cytokinesis.
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Protein Aliases: 5E5 antigen; mSIR2L2; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; Regulatory protein SIR2 homolog 2; silent information regulator 2; silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2; SIR2-like protein 2; sir2-related protein type 2; sirtuin type 2; sirtuin-2
Gene Aliases: 5730427M03Rik; SIR2; SIR2L; SIR2L2; SIRT2