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Rockland

SKG-1 Polyclonal Antibody

View all (25) SGK1 antibodies
Datasheet
Protocols
Questions & Answers
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

200-401-844

Applications Tested Dilution Publications

Western Blot (WB)

 1:500-1:2,000 -

Immunohistochemistry (Paraffin) (IHC (P))

 10-20 µg/mL -

ELISA (ELISA)

 1:4,000-1:16,000 -

Immunoprecipitation (IP)

 1:500-1:3,000 -
Product Specifications

Species Reactivity

 Human, Mouse, Rat

Host/Isotype

 Rabbit / IgG

Class

 Polyclonal

Type

 Antibody

Immunogen

SKG-1 Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a C-Terminal region near amino acids 400-431 of human SGK -1.
View immunogen

Conjugate

 Unconjugated

Form

 Liquid

Concentration

 5 mg/mL

Purification

 Protein A

Storage buffer

 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl

Contains

 0.01% sodium azide

Storage conditions

 -20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Anti-SKG-1 Antibody is directed against human SGK-1 protein. A BLAST analysis was used to suggest reactivity with this protein from human, macaque and chimpanzee sources based on 100% homology for the immunogen sequence. This antibody is expected to cross react with SGK-1 homologues from mouse, rat, dog, chicken, bovine, rabbit and spiny dogfish based on an 92% sequence homology for the immunogen (12/13) from these sources. Cross reactivity with SGK-1 homologues from other sources has not been determined.

Target Information

Serum and glucocorticoid-regulated protein kinase 1 (SGK1) is a member of the AGC family of serine/threonine kinases that plays an important role in cellular stress response and cell survival. SGK1 is transcriptionally activated by numerous stimuli, including serum, glucocorticoids, osmotic stress, and hormones. SGK1 functions as a regulator of cell survival and ion channels and transporters such as ENaC or KCNA3/Kv1. 3. It phosphorylates and negatively regulates pro-apoptotic FOXO3A. SGK1 is thought to play an essential function in nephropathy and cardiovascular development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: serine/threonine protein kinase SGK; Serine/threonine-protein kinase Sgk1; serum and glucocorticoid-dependent protein kinase; Serum/glucocorticoid-regulated kinase 1; Sgk1 variant i3

Gene Aliases: SGK; SGK1

UniProt ID: (Human) B7UUP7, (Mouse) Q9WVC6

Entrez Gene ID: (Human) 6446, (Mouse) 20393, (Rat) 29517

Molecular Function: protein modifying enzyme

Function(s)
regulation of cell growth protein phosphorylation sodium ion transport cellular sodium ion homeostasis apoptotic process response to stress cellular response to DNA damage stimulus microtubule depolymerization long-term memory regulation of blood pressure visual learning positive regulation of sodium ion transport peptidyl-serine phosphorylation positive regulation of cell growth regulation of cell migration negative regulation of microtubule polymerization positive regulation of transporter activity ion transmembrane transport intracellular signal transduction regulation of cell proliferation regulation of apoptotic process negative regulation of apoptotic process glucocorticoid mediated signaling pathway neuron projection morphogenesis positive regulation of dendrite morphogenesis regulation of catalytic activity regulation of sequence-specific DNA binding transcription factor activity regulation of cell cycle regulation of gastric acid secretion renal sodium ion absorption phosphorylation cellular response to insulin stimulus regulation of protein localization
Process(es)
protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity calcium channel regulator activity protein binding ATP binding potassium channel regulator activity sodium channel regulator activity chloride channel regulator activity 3-phosphoinositide-dependent protein kinase binding cofactor binding tau protein binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups phosphatidylinositol binding
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