MA5-17174 targets SKP1 in FACS, IHC, pep-ELISA, and WB applications and shows reactivity with Human samples.
The MA5-17174 immunogen is purified recombinant fragment of human SKP1 expressed in E. Coli.
MA5-17174 detects SKP1 which has a predicted molecular weight of approximately 19kDa.
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cyclin A/CDK2-associated p19; cyclin A/CDK2-associated protein p19; Cyclin-A/CDK2-associated protein p19; OCP-2; OCP-II; Organ of Corti protein 2; Organ of Corti protein II; p19A; p19skp1; RNA polymerase II elongation factor-like protein; RNA polymerase II elongation factor-like protein OCP2; S-phase kinase-associated protein 1; S-phase kinase-associated protein 1A; SIII; Transcription elongation factor B polypeptide 1-like
Gene Aliases: EMC19; OCP-II; OCP2; p19A; SKP1; SKP1A; TCEB1L