SLC22A12 is required for efficient urate re-absorption in the kidney. SLC22A12 regulates blood urate levels. SLC22A12 mediates saturable urate uptake by facilitating the exchange of urate against organic anions.The protein encoded by this gene is a urate transporter and urate-anion exchanger which regulates the level of urate in the blood. This protein is an integral membrane protein primarily found in kidney. Two transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Organic anion transporter 4-like protein; Renal-specific transporter; RST; solute carrier family 22 (organic anion/cation transporter), member 12; solute carrier family 22 (organic anion/urate transporter), member 12; solute carrier family 22 (organic cation transporter)-like 2; Solute carrier family 22 member 12; Urate anion exchanger 1; urate transporter 1
Gene Aliases: AI987855; OAT4L; OATL4; RST; SLC22A12; Slc22al2; UNQ6453/PRO34004; URAT1
Molecular Function: secondary carrier transporter