|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from the C-terminal region of human ORCTL-2|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 150mM NaCl, 50% glycerol|
|Contains||0.02% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
ORCTL2 (organic cation transporter-like protein 2), also known as HET, ITM, BWR1A, IMPT1, TSSC5, BWSCR1A, SLC22A1L, p45-BWR1A or SLC22A18, is a 424 amino acid multi-pass membrane protein that localizes at the apical membrane surface of renal proximal tubules. ORCTL2 is expressed at high levels in the kidney, liver, colon and in fetal renal proximal tubules and present at lower levels in heart, brain and lung. Belonging to the major facilitator superfamily, ORCTL2 may act as a transporter of organic cations based on a proton efflux antiport mechanism and may also play a role in the transport of chloroquine and quinidine-related compounds in kidney. Defects in ORCTL2 are associated with breast and lung cancer and are the cause of rhabdomyosarcoma type 1, a malignant tumor derived from striated muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.