Immunogen sequence: VQSILRFGRHR LNPENRTLGS LRNILYLLHQ RVRRFGIMGL YK
Highest antigen sequence identity to the following orthologs - mouse 93%, rat 93%.
This protein encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 34 kDa peroxisomal membrane protein; peroxisomal membrane protein (34kD); Peroxisomal membrane protein PMP34; PMP34; solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17; Solute carrier family 25 member 17
Gene Aliases: PMP34; SLC25A17
UniProt ID: (Human) O43808
Entrez Gene ID: (Human) 10478
Molecular Function: RNA binding protein amino acid transporter calcium-binding protein calmodulin intracellular calcium-sensing protein mitochondrial carrier protein nucleic acid binding ribosomal protein transfer/carrier protein transporter