Sequence of this protein is as follows: TQFPKCSTLA NIGRTNIYKN KKDYYDMYEP EGVKIFRCPS PIYFANIGFF RRKLIDAVGF SPLRILRKRN KALRKIRKLQ KQGLLQVTPK GFICTVDT
SLC26A3 is a chloride/bicarbonate exchanger that is involved in absorption inside the colon. SLC26A3 helps mediate electrolyte and fluid absorption. The protein encoded by the SLC26A3 gene is a transmembrane glycoprotein that functions as a sulfate transporter, and it is localized to the mucosa. The chloride ions transported by SLC26A3 cross the cell membrane in exchange for biocarbonate ions. SLC26A3 is localized in the mucosa of the lower intestinal tract, specifically the apical membrane of the columnar epithelium and in some goblet cells. Diseases associated with SLC26A3 protein dysfunction include congenital chloride diarrhea and congenital secretory chloride diarrhea 1.
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Protein Aliases: Chloride anion exchanger; Down-regulated in adenoma; down-regulated in adenoma protein; Protein DRA; solute carrier family 26 (anion exchanger), member 3; Solute carrier family 26 member 3; solute carrier family 26, member 3
Gene Aliases: CLD; DRA; SLC26A3
UniProt ID: (Human) P40879
Entrez Gene ID: (Human) 1811
Molecular Function: transporter