|Tested species reactivity||Mouse|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Fusion protein containing the C-terminal region of mouse SLC26A7. [Swiss-Prot# Q24JS8]|
|Storage buffer||tris glycine with 0.15M NaCl|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Do not boil samples prior to Western Blot.
SLC26A7 (solute carrier family 26 member 7) is a chloride-base exchanger and/or chloride transporter that is expressed on basolateral membrane of acid-secreting cells in renal outer medullary collecting duct (OMCD) and in gastric parietal cells also. SLC26A7 belongs to conserved family of anion transporters SLC26 isoforms which display tissue-specific expression patterns in epithelial cells and several SLC26 members function as chloride/bicarbonate exchangers that include SLC26A3 (DRA), SLC26A4 (pendrin), SLC26A6 (PAT1 or CFEX), SLC26A7, and SLC26A9 among which SLC26A7 and SLC26A9 also function as chloride channels. In renal tissues, Slc26a7 co-localizes with AE1, a well-known Cl-/HCO3- exchanger, on the basolateral membrane of (acid-secreting) A-intercalated cells in OMCD cells, and in the gastric tissue, SLC26A7 co-localizes with AE2, a major Cl-/HCO3- exchanger, on the basolateral membrane of acid secreting parietal cells. SLC26A7 acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. SLC26A7 maintains the electrolyte/acid-base homeostasis in kidneys by acting as a distal excretory segment-specific anion exchanger, specifically chloride, and plays a major role in gastric acid secretion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.