SLC7A8 is sodium-independent, high-affinity transport of large neutral amino acids. It has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. SLC7A8 also plays a role in basolateral (re)absorption of neutral amino acids.
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Protein Aliases: hLAT2; integral membrane protein E16H; L-type amino acid transporter 2; Large neutral amino acids transporter small subunit 2; solute carrier family 7 (amino acid transporter light chain, L system), member 8; solute carrier family 7 (amino acid transporter, L-type), member 8; solute carrier family 7 (cationic amino acid transporter, y+ system), member 8; Solute carrier family 7 member 8
Gene Aliases: LAT2; LPI-PC1; SLC7A8
UniProt ID: (Human) Q9UHI5
Entrez Gene ID: (Human) 23428
Molecular Function: transporter