SLCO1B3, also known as OATP8 or OATP1B3, is a member of Organic Anion Transporting Polypeptides (OATPs) which are sodium-independent organic anion transporters mediating the uptake of a wide range of structurally diverse endogenous and exogenous compounds including bile acids, hormone conjugates, peptides, toxins, as well as a multitude of therapeutic drugs. SLCO1B3 is specifically expressed in liver under normal condition, while its expression has also been observed in cancer tissues like colon, prostate and pancreas. The molecular mass of SLCO1B3 is highly dependent on the glycosylation modification (deglycosylated form of 65 kDa, fully-glycosylated form of 120 kDa).
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Protein Aliases: Liver-specific organic anion transporter 2; liver-specific organic anion transporter 3TM13; LST-2; OATP-8; Organic anion transporter 8; organic anion transporter LST-3c; Organic anion-transporting polypeptide 8; solute carrier family 21 (organic anion transporter), member 8; Solute carrier family 21 member 8; Solute carrier organic anion transporter family member 1B3; solute carrier organic anion transporter family, member 1B3
Gene Aliases: HBLRR; LST-2; LST-3TM13; LST2; LST3; OATP-8; OATP1B3; OATP8; SLC21A8; SLCO1B3
UniProt ID: (Human) Q9NPD5
Entrez Gene ID: (Human) 28234
Molecular Function: transporter