|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:20|
|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Bovine, Human, Mouse, Rhesus monkey, Rat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant protein derived from the N-terminal region of human Smad2 protein.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
SMAD2, also known as MADH2 or MAD2 regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. Smad2 interacts with the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation into the nucleus is a central event in TGF beta signaling. Phosphorylation of threonine 8 in the calmodulin-binding region of the MH1 domain by extracellular signalregulated kinase 1 (ERK1) enhances Smad2 transcriptional activity, which is negatively regulated by calmodulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hMAD-2; hSMAD2; JV18-1; MAD homolog 2; Mad-related protein 2; MADH2; MADR2; mMad2; mother against DPP homolog 2; Mothers against decapentaplegic homolog 2; Mothers against decapentaplegic-like protein 2; Mothers against DPP homolog 2; Sma- and Mad-related protein 2; SMAD 2; SMAD family member 2; SMAD, mothers against DPP homolog 2; SMAD2
Gene Aliases: 7120426M23Rik; BOS_22266; EGK_09664; hMAD-2; hSMAD2; JV18; JV18-1; MADH2; MADR2; mMad2; Smad-2; SMAD2
Molecular Function: transcription factor
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