Sequence of this protein is as follows: VCVNPYHYQR VETPVLPPVL VPRHTEIPAE FPPLDDYSHS IPENTNFPAG IEPQSNIPET PPPGYLSEDG ETSDHQMNHS MDAGSPNLSP NPMSPAHNNL DL
SMAD3 belongs to the SMAD family of proteins. They are similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.
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Protein Aliases: DKFZp586N0721; DKFZp686J10186; hMAD-3; hSMAD3; JV15-2; MAD homolog 3; mad homolog JV15-2; mad protein homolog; MAD, mothers against decapentaplegic homolog 3; MAD-3; mad3; MGC60396; Mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; SMA- and MAD-related protein 3; SMAD; SMAD 3; SMAD family member 3; SMAD, mothers against DPP homolog 3
Gene Aliases: HSPC193; HsT17436; JV15-2; LDS1C; LDS3; MADH3; SMAD3
UniProt ID: (Human) P84022
Entrez Gene ID: (Human) 4088