MA5-15793 targets SMAD5 in FACS, IF, IHC, and WB applications and shows reactivity with Human and Rat samples.
The MA5-15793 immunogen is purified recombinant fragment of human SMAD5 expressed in E. Coli.
MA5-15793 detects SMAD5 which has a predicted molecular weight of approximately 52kDa.
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). SMAD5 is required for normal development of the cardiovascular system in vivo; lack of the SMAD5 gene results in apoptosis of cardiac myocytes. 3 Upregulation of SMAD5 has been reported to mediate apoptosis of gastric epithelial cells induced by Helicobacter pylori infection. Tissue specificity: Ubiquitous.
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Protein Aliases: DWFC, JV5-1, MADH5, MAD, mothers against decapentaplegic homolog 5; JV5-1; MAD homolog 5; MAD, mothers against decapentaplegic homolog 5; Mothers against decapentaplegic homolog 5; mothers against decapentaplegic, drosophila, homolog of, 5; mothers against DPP homolog 5; SMA- and MAD-related protein 5; SMAD 5; SMAD family member 5; SMAD, mothers against DPP homolog 5
Gene Aliases: DWFC; JV5-1; MADH5; SMAD5
Molecular Function: transcription factor