MA5-15687 targets SMAD6 in WB applications and shows reactivity with Human samples.
The MA5-15687 immunogen is purified recombinant fragment of human SMAD6 expressed in E. Coli.
MA5-15687 detects SMAD6 which has a predicted molecular weight of approximately 53kDa.
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: HsT17432; MAD homolog 6; MADH6; MADH7; Mothers against decapentaplegic homolog 6; mothers against decapentaplegic, drosophila, homolog of, 6; SMAD 6; SMAD family member 6; SMAD, mothers against DPP homolog 6; SMAD6
Gene Aliases: AOVD2; HsT17432; MADH6; MADH7; SMAD6
UniProt ID: (Human) O43541
Entrez Gene ID: (Human) 4091
Molecular Function: transcription factor