Active Motif

SMARCB1 Monoclonal Antibody (2C2)

Product Image Gallery

SMARCB1 Antibody in Immunocytochemistry (ICC/IF) — SMARCB1 antibody (mAb) (Clone 2C2) tested by immunofluorescence. Top: HeLa cells stained with SMARCB1 antibody (mAb). Bottom: Hoechst staining.

SMARCB1 Antibody in Western Blot (WB) — SMARCB1 antibody (mAb) (Clone 2C2) tested by Western blot. SMARCB1 antibody detection by Western blot. The analysis was performed using 20 µg of Jurkat nuclear extract and SMARCB1 antibody at a 2 µg/ml dilution.

Product Details

61649

Applications	Tested Dilution	Publications
Western Blot (WB)	0.5-2 µg/mL	-
Immunocytochemistry (ICC/IF)	2-10 µg/mL	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Mouse / IgG2a
Class	Monoclonal
Type	Antibody
Clone	2C2
Immunogen	This antibody was raised against full-length recombinant human SMARCB1 protein. View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Protein A
Storage buffer	PBS, pH 7.5, with 30% glycerol
Contains	0.035% sodium azide
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_2793719

Target Information

The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF2alpha) and Brg-1 (also designated SNF2beta) are the ATPase subunits of the mammalian SWI-SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI-SNF complex. Addition of Ini1, BAF155 and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits are thought to play regulatory roles. hSNF2L and hSNF2H both appear to be homologs of Drosophila ISWI, a Brm related ATPase that is present in chromatin remodeling complexes other than SWI/SNF, including the NURF (nucleosome remodeling factor).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BAF47; BRG1-associated factor 47; BRG1-associated factor 47 (BAF47); hSNF5; Integrase interactor 1 protein; malignant rhabdoid tumor suppressor; protein phosphatase 1, regulatory subunit 144; SNF5 homolog; Sucrose nonfermenting yeast homolog like 1; sucrose nonfermenting, yeast, homolog-like 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; SWI/SNF-related matrix-associated protein; SWI10; TYE4

Gene Aliases: BAF47; CSS3; hSNFS; INI1; MRD15; PPP1R144; RDT; RTPS1; Sfh1p; SMARCB1; SNF5; SNF5L1; Snr1; SWNTS1

UniProt ID: (Human) Q76N08

Entrez Gene ID: (Human) 6598

Molecular Function: DNA metabolism protein nucleic acid metabolism protein