Immunogen sequence: DNGRGMTSKQL NNWAVYRLSK FTRQGDFESD HSGYVRPVPV PRSLNSDISY FGVGGKQAVF FVGQSARMIS KPADSQDVHE LVLSKED
Highest antigen sequence identity to the following orthologs - mouse 97%, rat 98%.
Required for maintenance of X inactivation in females and hypermethylation of CpG islands associated with inactive X. Involved in a pathway that mediates the methylation of a subset of CpG islands slowly and requires the de novo methyltransferase DNMT3B. Required for DUX4 silencing in somatic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: KIAA0650; SMC hinge domain-containing protein 1; Structural maintenance of chromosomes flexible hinge domain-containing protein 1
Gene Aliases: KIAA0650; SMCHD1
UniProt ID: (Human) A6NHR9
Entrez Gene ID: (Human) 23347