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Invitrogen
SMG1 Recombinant Rabbit Monoclonal Antibody (5N10C7)
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FIGURE: 1 / 1
SMG1 Antibody (MA5-42693) in WB
Western blot analysis of SMG1 in extracts of various cell lines. Samples were incubated with SMG1 Monoclonal antibody (Product # MA5-42693) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
MA5-42693
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
5N10C7
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 3562-3661 of human SMG1 (Q96Q15).
Conjugate
Form
Liquid
Concentration
0.75 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2911834
Product Specific Information
Immunogen sequence: LIQKNLATSA DTPPSTVPGT GKSVACSPKK AVRDPKTGKA VQERNSYAVS VWKRVKAKLE GRDVDPNRRM SVAEQVDYVI KEATNLDNLA QLYEGWTAWV
Target Information
This gene encodes a protein involved in nonsense-mediated mRNA decay as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hSMG-1; Lambda-interacting protein; Lambda/iota protein kinase C-interacting protein; Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1; phosphatidylinositol 3-kinase-related protein kinase; PI-3-kinase-related kinase SMG-1; Serine/threonine-protein kinase SMG1; SMG-1; smg-1 homolog, phosphatidylinositol 3-kinase-related kinase; SMG1 phosphatidylinositol 3-kinase-related kinase
Gene Aliases: 2610207I05Rik; 5430435M13Rik; 61E3.4; ATX; C130002K18Rik; KIAA0421; LIP; mKIAA0421; RGD1563508; SMG1
UniProt ID: (Human) Q96Q15, (Mouse) Q8BKX6
Entrez Gene ID: (Human) 23049, (Mouse) 233789, (Rat) 691397
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
telomeric DNA binding
poly(A) RNA binding
metal ion binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
phosphotransferase activity, alcohol group as acceptor
protein dimerization activity
non-receptor serine/threonine protein kinase
transporter
protein modifying enzyme
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
telomere maintenance
DNA repair
mRNA export from nucleus
response to stress
peptidyl-serine phosphorylation
protein autophosphorylation
phosphatidylinositol phosphorylation
double-strand break repair via homologous recombination
cellular response to DNA damage stimulus
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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