Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates.
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Protein Aliases: flavin containing amine oxidase; flavin-containing spermine oxidase; PAO-1; Polyamine oxidase 1; putative cyclin G1 interacting protein; Spermine oxidase
Gene Aliases: B130066H01Rik; C20orf16; PAO; PAO-1; PAO1; PAOH; PAOH1; SMO; SMOX; UNQ3039/PRO9854