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Product Details
CF800167
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI1A6
Immunogen
Full length human recombinant protein of human SNAI2 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemopoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC10182; Neural crest transcription factor Slug; Protein snail homolog 2; slug (chicken homolog), zinc finger protein; snail family zinc finger 2; snail homolog 2; Zinc finger protein SNAI2
Gene Aliases: SLUG; SLUGH; SLUGH1; SNAI2; SNAIL2; WS2D
UniProt ID: (Human) O43623
Entrez Gene ID: (Human) 6591
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
sequence-specific DNA binding
metal ion binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
epithelial to mesenchymal transition
epithelial to mesenchymal transition involved in endocardial cushion formation
cell migration involved in endocardial cushion formation
transcription, DNA-templated
negative regulation of cell adhesion involved in substrate-bound cell migration
Notch signaling pathway
sensory perception of sound
negative regulation of keratinocyte proliferation
negative regulation of vitamin D biosynthetic process
neural crest cell development
positive regulation of cell migration
negative regulation of chondrocyte differentiation
regulation of chemokine production
negative regulation of cell adhesion mediated by integrin
positive regulation of histone acetylation
negative regulation of catenin import into nucleus
desmosome disassembly
pigmentation
negative regulation of DNA damage response, signal transduction by p53 class mediator
cellular response to fibroblast growth factor stimulus
positive regulation of fat cell differentiation
regulation of osteoblast differentiation
white fat cell differentiation
palate development
canonical Wnt signaling pathway
epithelium development
cartilage morphogenesis
regulation of branching involved in salivary gland morphogenesis
negative regulation of vitamin D receptor signaling pathway
cellular response to epidermal growth factor stimulus
cellular response to ionizing radiation
negative regulation of canonical Wnt signaling pathway
negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of stem cell proliferation
regulation of bicellular tight junction assembly
negative regulation of anoikis
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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