MA5-15791 targets SNAI1 in WB applications and shows reactivity with Human samples.
The MA5-15791 immunogen is purified recombinant fragment of human SNAI1 expressed in E. Coli.
MA5-15791 detects SNAI1 which has a predicted molecular weight of approximately 29kDa.
Zinc finger protein SNAI1 (SNAIL)is a zinc finger transcriptional repressor which down regulates the expression of the ectodermal gene within the mesoderm and functions to form the mesoderm and neural crest. It is reported that SNAI1 acts as an important factor of tumor invasion as evidenced by its role in E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT). In human breast cancer, the expression of SNAI1 and/or the homologous SNAI2 (Slug) has been associated with E-cadherin repression, local or distant metastasis, tumor recurrence, or poor prognosis in different tumor series. It is also reported that Snail 1 protein in the stromamay be anew putative prognosis marker for colon tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Protein sna; Protein snail homolog 1; SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1, protein sna; snail 1 homolog; snail 1 zinc finger protein; snail 1, zinc finger protein; snail family zinc finger 1; snail homolog 1; Zinc finger protein SNAI1
Gene Aliases: dJ710H13.1; SLUGH2; SNA; SNAH; SNAI1; SNAIL; SNAIL1
UniProt ID: (Human) O95863
Entrez Gene ID: (Human) 6615