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|Tested species reactivity||Bovine, Human, Rat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human a-SNAP protein.|
|Storage buffer||PBS, pH 7.5, with 50% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||1:5000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control for this product is rat brain lysate.
SNAPs (solubleNSFattachment proteins), acting in concert with SNAREs ( S N A P r e c eptors) and the N - ethylmaleimide- s e nsitive f u sion protein (NSF) are required for the fusion of transport vesicles to their target membranes in synaptic transmission, intra-Golgi transport, endosome-toendosome fusion and transcytotic vesicles-to-plasma membrane transport. Vesicle-to-target membrane docking (initial contact) occurs when the vesicle SNARE binds to its cognate target membrane SNARE. a-SNAP (or b-SNAP in brain) then binds to this docking complex and mediates the binding of NSF and thus the formation of a 20S fusion particle. It is thought that, once NSF is bound, ATP hydrolysis by NSF initiates the fusion process.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
alpha soluble NSF attachment protein; alpha-SNAP; alpha-soluble NSF attachment protein; N-ethylmaleimide sensitive fusion protein attachment protein alpha; N-ethylmaleimide-sensitive factor attachment protein alpha; N-ethylmaleimide-sensitive factor attachment protein, alpha; SNAP-alpha; Synaptosomal-Associated Protein alpha
alpha-SNAP; BOS_17742; NAPA; Snap; SNAPA