Positive Control: Human skin tissue lysate, A549, SH-SY-5Y, SiHa, rat epididymis tissue, human colon tissue, human breast cancer tissue.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms.
Protein Aliases: MGC8664; SNX1A; sorting nexin 1A; Sorting nexin-1
Gene Aliases: HsT17379; SNX1; VPS5
UniProt ID: (Human) Q13596
Entrez Gene ID: (Human) 6642