SNX27 encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.
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Protein Aliases: MAP-responsive gene protein; methamphetamine (MAP) responsive transcript 1; methamphetamine-responsive transcript 1; Methamphetamine-responsive transcript 1 protein; PDZ protein Mrt1; PDZ-protein Mrt1; RP11-98D18.12-005; Sorting nexin-27
Gene Aliases: 5730552M22Rik; ESTM45; ESTM47; KIAA0488; MRT1; MY014; R75405; SNX27