This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain a SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.
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Protein Aliases: MST155; MSTP155; OTTHUMP00000040083; Protein SDP1; RP11-266C7.10; SH3 and PX domain-containing protein 1; SH3 and PX domain-containing protein 3A; Sorting nexin-9; Wiskott-Aldrich syndrome protein (WASP) interactor protein
Gene Aliases: SDP1; SH3PX1; SH3PXD3A; SNX9; WISP
UniProt ID: (Human) Q9Y5X1
Molecular Function: scaffold/adaptor protein