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|Tested species reactivity||Mouse|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Recombinant protein derived from the N-terminal region of the mouse SOCS-1 (Suppressor of Cytokine Signaling-1, also known as SSI-1) protein.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
SOCS-1, Cish1, Cish7, SSI-1, JAB
JAK2-binding protein, STAT-induced STAT inhibitor 1, cytokine inducible SH2-containing protein 1, cytokine inducible SH2-containing protein 7, suppressor of cytokine signaling 1, CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3, JAK binding protein, STAT induced SH3 protein 1, TIP-3, cytokine-inducible SH2 protein 1