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Product Details
CF503039
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI8G3
Immunogen
Full length human recombinant protein of human SOCS3 produced in HEK293 cell.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CIS-3; Cytokine-inducible SH2 protein 3; MGC71791; SOCS-3; SSI-3; STAT-induced STAT inhibitor 3; Suppressor of cytokine signaling 3
Gene Aliases: ATOD4; CIS3; Cish3; SOCS-3; SOCS3; SSI-3; SSI3
UniProt ID: (Human) O14543
Entrez Gene ID: (Human) 9021
response to hypoxia
negative regulation of protein kinase activity
JAK-STAT cascade
aging
response to heat
response to gamma radiation
protein ubiquitination
cytokine-mediated signaling pathway
organ regeneration
response to food
response to estradiol
response to lipopolysaccharide
response to progesterone
response to insulin
regulation of growth
response to drug
negative regulation of tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of apoptotic process
positive regulation of cell differentiation
negative regulation of JAK-STAT cascade
negative regulation of insulin receptor signaling pathway
negative regulation of inflammatory response
response to glucocorticoid
regulation of interferon-gamma-mediated signaling pathway
branching involved in labyrinthine layer morphogenesis
placenta blood vessel development
trophoblast giant cell differentiation
spongiotrophoblast differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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