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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant full length human SORD|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 50% glycerol|
|Contains||0.1% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:200|
|Western Blot (WB)||1:500-1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody detects endogenous protein at a molecular weight of 38 kDa.
Purity is >95% by SDS-PAGE.
Sorbitol Dehydrogenase, also known as L-iditol 2-dehydrogenase, SORD or SORD1, is a 357 amino acid member of the zinc-containing alcohol dehydrogenase family. Widely expressed with highest expression in kidney and in the lens of the eye, Sorbitol Dehydrogenase enzymatically catalyzes the zinc-dependent interconversion of polyols, such as such as sorbitol and xylitol, to their respective ketoses. These reactions require NAD+ as an oxidizing agent and, together with Aldose Reductase, they comprise the sorbitol pathway that is involved in sugar production. Sorbitol Dehydrogenase deficiency leads to defects in this pathway and a subsequent accumulation of sorbitol within the cell, a condition that may be associated with diabetic complications such as cataracts and microvascular problems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
epididymis secretory sperm binding protein Li 95n; L-iditol 2-dehydrogenase; Sorbitol dehydrogenase; sorbitol dehydrogenase 1; SORD; SORD 1; SORD1
HEL-S-95n; Sdh-1; Sdh1; Sodh-1; SORD; SORD1